Séminaire scientifique « Réponse immunitaire du ver à soie »

Un séminaire scientifique a lieu le vendredi 15 septembre 2017 à 14h30, à la bibliothèque de l’Institut Pasteur de la Guyane.

Dans le contexte du cours d’entomologie médicale qui débute le 18 septembre, Dr Ottavia Romoli de l’université de Padoue (Italie) présentera son sujet de recherche « Antimicrobial peptide-mediated immune response in different geographical strains of the silkworm Bombyx mori ».

Voici un résumé de la présentation :

The domesticated silkworm Bombyx mori has been extensively studied as a model organism for Lepidoptera genetics, for its economic value in silk production and for its recent use in different biotechnological applications.

Since silkworm infectious diseases can cause crop losses of ~27–35%, a great attention has been posed on the study of B. mori immune mechanisms. B. mori has an innate immune system, whose main effectors are the antimicrobial peptides (AMPs).

Silkworm strains are commonly grouped into four geographical types (Japanese, Chinese, European and Tropical), generally characterised by a variable susceptibility to infections.

We aimed to understand which are the mechanisms at the basis of this diverse strain sensitivity: we evaluated the differential sensitivity of four geographical B. mori strains to oral infections with Enterococcus mundtii or Serratia marcescens.

While the tolerance to E. mundtii was related to the specific composition of the AMP cocktail, the resistance to S. marcescens was associated with the capability to activate the systemic AMP production.